In this study, the crystal structure of the leptin receptor (LEPR) complex with a monoclonal antibody (9F8 Fab) was explored to predict antigen-antibody (Ag-Ab) interactions using bioinformatics tools. In silico small molecule antibody technology has been successful in the design of novel biologicals for the diagnosis of diseases and therapeutic interventions. Moreover, the macromolecules have limited penetration into the tissue and blood/brain barrier even might induce severe side effects like induction of anti-idiopathic antibodies and immune complex formation. Hence, the complexity of existing therapy and adverse effects emphasizes the need for an alternative approach for the management of immune dysfunction associated with obesity. The synthetic immunotherapeutic carry a degree of risk, time-consuming and expensive. These disorders are managed through antibiotics and by cytokines replacement. The treatment of obesity and its associated immune-mediated diseases is challenging due to the impaired function of the leptin system. Obesity is characterized by a state of low-grade, chronic inflammation in addition to disturbing levels of circulating nutrients and metabolic hormones. NIN-TATA Centre for Excellence in Public Health Nutrition, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, Telangana, IndiaĮxcess adiposity in obese inhibits negatively impacts immune function and host defense. Manne Munikumar, Pittla Naresh, KV Radha Krishna » Section 1: 5 th IUPHAR WCP-NP, 2019 INDIA Young Scientist Presentationĭesign of Small Peptides Antagonist Against Leptin Receptor for the Treatment of Obesity and its Associated Immune-Mediated Diseases: In Silico Approach IPS Poster Presentations – Traditional Medicine IPS Poster Presentations – Systemic Disorders IPS Poster Presentations – Epidemiology/Vigilance POSTER PRESENTATION - Health Effects of Medicinal Productĥ1 st Annual Conference of Indian Pharmacological Society (IPS) Poster Presentation - Traditional Medicine 5 th IUPHAR WCP-NP, 2019 INDIA & 51st Annual Conference of IPSCON-2019.
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